-synuclein, and that is a principal part of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, and that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) worry, advise that dysfunction of the intracellular proteinase devices, for instance ubiquitin-proteasome procedure or lysosomal procedure, which eliminates unneeded pois
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